Thursday 7th October 2004

Moderator:
Professor Mark C. Glassy (Rajko Medinica Research Foundation, Shantha West, UCSD, USA)

09.00-09.30
Keynote Lecture:
‘Antibody drugs: In a class of their own – features and benefits of developing antibodies as drugs’
Ron Jackson (Cambridge Antibody Technology, UK)

SESSION 6:
INFECTIOUS DISEASES

Moderators:
Roberto Burioni (University of Ancona/University ‘Vita e Salute san Raffaele Milan, Italy)
Mirek Gorny (New York University, USA)

09.30-09.50
‘Cross-neutralizing activity of human monoclonal antibody depends on the recognition of a conserved GPGR V3 motif of HIV-1’
Miroslaw K. Gorny, P. Zhong, K. Revesz, B. Volsky, C. Williams, P. Nyambi, S. Zolla-Pazner (New York University School of Medicine, New York, USA)

9.50-10.10
‘IgM monoclonal proliferation from HCV-positive patients binds NS3 HCV protein’
V. De Re, S. De Vita, D. Sansonno, M.P. Simula, D. Gasparotto, F.A. Tucci (Centro di Riferimento Oncologico, Aviano, Italy)

10.10-10.40
Coffee Break & Posters

10.40-11.00
‘Evaluation of the biological activity of Aurexis®, a humanized mAb for the first-line treatment of severe S. aureus infections in combination with antibodies’
Jeff T. Hutchins, Li Zhang, Joseph M. Patti (Inhibitex Inc., Alpharetta, Georgia, USA)

11.00-11.20
‘Identification of an immune receptor on primary B cell leukemia cells down-regulating a Th1 immune response’
Kathy Bowdish (Alexion Technologies Inc., USA)

11.20-11.50
Keynote Lecture:
‘Phage display-generated recombinant Fabs for the study of human antiviral immunoglobulin subpopulations’
Roberto Burioni, N. Mancini, S. Carletti, A. Grieco, E. Belardinelli, M. Mammarella, M. Sampaolo, F. Canducci, M. Clementi (University of Ancona/University ‘Vita e Salute san Raffaele Milan, Italy)

11.50-12.30
Keynote Lecture:
‘The future of antibodies versus small molecule pharmaceuticals’
Jim W. Larrick (Panorama Research Institute, Mountain View, California, USA)

12.30-14.00
Lunch Break & Posters

SESSION 7:
MOLECULAR BIOLOGY I

Moderators:
Jim Larrick (Panorama Research Institute, Mountain View, California, USA)
Sachev Sidhu (Genentech Inc., South San Francisco, USA)

14.00-14.30
‘A binary code for antigen recognition’
Sachev S. Sidhu (Genentech Inc., South San Francisco, USA)

14.30-14.50
‘Combinatorial yeast mating: Applications to affinity maturation of Fab antibody fragments’
Simon Hufton (Dyax SA, Liege, Belgium)

14.50-15.10
‘Selection of highly stable human antibody fragments for compartmental therapeutic approaches’
Alcide Barberis (ESBATech AG, Zurich-Schlieren, Switzerland)

15.10-15.30
‘Rapid generation of functional human antibodies derived from Fab/phage display libraries’
J. Mullberg, T. Jostock, E. Brepoels, R. van Gool, M. Daukandt, A. Wehnert, R. van Hegelsom, D. Dransfield, D. Sexton, M. Devlin, M. Vanhove (Dyax SA, Liege, Belgium/Dyax Corp, Cambridge, Massachusetts, USA)

15.30-16.00
Tea Break & Posters

SESSION 8:
MOLECULAR BIOLOGY II

Moderators:
Jim Larrick (Panorama Research Institute, Mountain View, California, USA)
Sachev Sidhu (Genentech Inc., South San Francisco, USA)

16.00-16.20
‘Optimising antibody drugs by ribosome and phage display’
Ralph Minter (Cambridge Antibody Technology, UK)

16.20-16.40
‘Identification of potent and specific membrane type serine protease inhibitors using phage display’
Andrew E. Nixon, Rene Hout, Nicole Hoebers, Que Nguyen (Dyax Corp, Cambridge, Massachusetts, USA)

16.40-17.00
‘Generation of a recombinant human anti-sperm antibody, RASA: Implications as an intravaginal spermicidal agent’
Kimberly D. Fralix, B. Xu, E.J. Norton, A.B. Diekman, M.A. Coppola, J.C. Herr (University of Virginia Medical Center, Charlottesville, Virginia, USA)

17.00-17.20
‘Construction of human naive Fab library and generation and characterization of Fab fragment against Met’
Brian Cao et al. (Van Andel Research Institute, Michigan, USA)

17.20-17.50
‘Fully human antibodies for the treatment of severe diseases derived from the Human Combinatorial Antibody Library HuCAL® GOLD’
Marlies Sproll (MorphoSys AG, Martinsreid, Germany)

18.00-19.00
HAH 2004 Welcome Reception & Poster Session
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